Vitamin B12 and Your Brain

Vitamin B12 and
 Your Brain

Arlene R. Taylor PhD

“I’m struggling with a fuzzy memory,” Jessie told the doctor. “At times I feel confused, can’t recall details well, and fear I’m heading down the path toward dementia!”

“You may be experiencing low levels of Vitamin B12 or cobalamin,” the physician replied. “A number of symptoms are associated with lover-than-desirable levels.”

Sure enough, a simple blood test showed that Jessie’s levels of B12 were low. Not even a real deficiency according to published ranges, mind you. Just low levels within the normal range. But low enough for Jessie to have produced symptoms of confusion and memory delays. Serious B12 deficiencies, on the other hand, have been associated with everything from severe damage to the brain and nervous system to symptoms of mania and psychosis.

The next thing Jessie wanted to know was
whether one could take too much B12.

“There is good news,” said the doctor,

“Vitamin B12 has extremely low toxicity and

even taking it in enormous doses appears

not to be harmful to healthy individuals.”

This water soluble vitamin is vitally important to the healthy functioning of the brain and nervous system. That’s likely one reason that, along with vitamin B6, it is

referred to as the brain vitamin. Of course, it plays a key role in other bodily functions, too. In the formation of blood, in the metabolism of every cell, and in the synthesis of DNA and fatty acids. Vitamin B12 is touted to be the largest and most structurally complicated vitamin currently known.

Recent studies have shown that up to 40% of the population may have B12 levels that range from low to shockingly low. Perhaps even more frightening, a B12 deficiency can contribute to brain shrinkage, a condition associated with decreased

brain function. According to a University of Oxford study, research is linking B12

deficiency with, among other negative consequences, Alzheimer’s disease. The Oxford

two-year randomized clinical trial is the largest to study the effect of B vitamins on

mild cognitive impairment, and one of the first disease-modifying trials in the

Alzheimer’s field to show positive results in humans.

Simple, you say. Just up your intake of Vitamin B12. Turns out that this may not be a

simple as you may think. For example, some individuals have been taking B12 in a

commonly available form known as cyanocobalamin. Ouch! It’s a derivative of

cyanide (think Agatha Christie murders).

According to Wikipedia, in the body this common synthetic form of cyanocobalamin is

converted to the physiological forms methylcobalamin and adenosylcobalmin, leaving

behind cyanide. Yes, you read it correctly. A small concentration of cyanide, but

cyanide nonetheless. Check the ingredient list for cyanocobalamin. If you see it listed,

you may want to run—not walk—the other way. What are manufacturers thinking? No

doubt that it is 100 times cheaper than the more desirable form: methylcobalamin.

So what can you do? If you eat meats and yogurt, they can be sources, although due

to common intestinal ailments many are unable to absorb vitamin B12 from their

intestines. Patches that deliver B12 are available; as are injections of B12, but few

people really want to go that route long term. B12 can be found in some fortified

cereals, as well.

Personally, as a vegetarian, I take delta-E every day. It contains the

methylcobalamin form of B12. Do you think I have time and energy to think about

cyanide? Not hardly! And since one of the ways in which B12 is absorbed is

sublingual, I’m doing more “sipping” these days than gulping.

Selected References

http://news.bbc.co.uk/2/hi/health/7595423.stm

http://www.alzheimersweekly.com/content/folic-acid-b6-b12-slows-memory-decline

http://en.wikipedia.org/wiki/Vitamin_B12

http://ods.od.nih.gov/factsheets/vitaminb12/

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